Medicinal Chemistry II – Important Questions with Answers – Unit Wise Guide (B pharma 5th semester solved)

Medicinal Chemistry II – Important Questions with Answers – Unit Wise Guide (B pharma 5th semester solved)

Section A

Unit-I Questions

1. Draw structures of any two antimetabolite antineoplastic agents.
2. Write structure, mechanism of action and uses of rabeprazole / proton pump inhibitors.
3. Give the synthesis, SAR and mechanism of action of cimetidine.
4. State the mechanism of action, adverse effects and uses of methotrexate.
5. Classify histamine receptors and mention their distribution in the human body.
6. What are antineoplastic agents?
7. Give the structure of promethazine.
8. Draw structure and write uses of diphenhydramine hydrochloride.

Unit-II Questions

1. Write the synthesis of isosorbide dinitrate / nitroglycerin.
2. Discuss the mechanism of action and uses of acetazolamide.
3. Describe calcium channel blockers along with their uses and examples.
4. What are anti-anginal drugs? Explain structure, synthesis and uses of nitrates.
5. Give synthesis and uses of furosemide.
6. Draw the structure of captopril.
7. Define hypertension.
8. Write the uses of minoxidil.
9. Draw structure and write mechanism of action of verapamil.
10. Draw structure and write uses of loop diuretics.

Unit-III Questions

1. Give structure and mechanism of action of any one antihyperlipidemic agent / HMG-CoA reductase inhibitor.
2. Discuss the role of digoxin/digitoxin in treatment of congestive heart failure.
3. Define oral anticoagulants and state their importance with examples.
4. Name and give structures of drugs used in congestive heart failure.
5. Give examples of anti-arrhythmic drugs.
6. Write mechanism of action and uses of lovastatin.

Unit-IV Questions

1. What are oral contraceptives? Give examples and structural classification.
2. Write structure and uses of testosterone.
3. Discuss mechanism of action and uses of sildenafil.
4. Explain the mechanism of action of estradiol.
5. Explain the action of L-thyroxine and normal thyroid test levels.
6. Write the mechanism of action and uses of prednisolone.

Unit-V Questions

1. Give the synthesis of benzocaine and explain its mechanism of action.
2. State the mechanism of action and uses of metformin.
3. Discuss the uses of glucosidase inhibitors.
4. What are sulfonylureas?
5. Discuss the advantages of amide local anesthetics over ester local anesthetics.
6. Write a short note on thiazolidinediones.
7. Discuss the metabolic pathway / chemistry and mechanism of action of insulin.

Section B

Unit-I Questions

1. Define and classify antihistaminic agents. Discuss structures, SAR, synthesis, mechanism of action and uses of first-generation H1 antihistaminic agents such as diphenhydramine.
2. Classify antineoplastic/alkylating agents and discuss SAR, synthesis and mechanism of action of mechlorethamine.
3. Discuss histamine receptors, their distribution and H2-receptor antagonists with SAR and mechanism of action.

Unit-II Questions

1. Classify diuretics and discuss SAR, synthesis and mechanism of action of thiazide diuretics/chlorothiazide.
2. What are antihypertensive agents? Classify them and discuss mode of action, SAR, synthesis and uses of methyldopa hydrochloride.
3. Write synthesis, uses and mechanism of action of nitrates such as nitroglycerin/isosorbide dinitrate.
4. Classify antianginal drugs and discuss synthesis and SAR of isosorbide dinitrate.
5. Write synthesis and mechanism of action of acetazolamide.

Unit-III Questions

1. Illustrate classification of antihyperlipidemic agents and discuss mechanism of action of HMG-CoA reductase inhibitors.
2. Discuss mode of action and synthesis of any two: Disopyramide phosphate, Warfarin, Dibucaine.
   • Disopyramide phosphate → Anti-arrhythmic drug
   • Warfarin → Anticoagulant
   • Dibucaine → Local anesthetic

Unit-IV Questions

1. Discuss nomenclature and stereochemistry of steroids.
2. Discuss classification of antithyroid drugs in detail.

Unit-V Questions

1. What are antidiabetic agents? Classify oral hypoglycemic agents and discuss SAR, mechanism of action and synthesis of sulfonylureas/tolbutamide.
2. Discuss SAR of local anesthetics with synthesis and mechanism of action of procaine.
3. Dibucaine (from mixed question above) also belongs to Local Anesthetics.

Section C

Unit-I Questions

1. Classify antineoplastic agents and discuss alkylating agents with structure and mechanism of action.
2. Discuss histamine receptors and H2-antagonists in detail.
3. Explain gastric proton pump inhibitors with examples.
4. Explain mechanism of action and uses of mercaptopurine.
5. Discuss antimetabolites with mechanism of action and adverse effects of methotrexate.

Unit-II Questions

1. Describe antihypertensive drugs and discuss ACE inhibitors with structures and mechanism of action.
2. Give classification of antianginal drugs and discuss structure, mechanism of action and uses of nitrates.
3. Discuss classification, SAR and synthesis of thiazide diuretics/chlorothiazide.

Unit-III Questions

1. Classify antiarrhythmic drugs and discuss structure and mechanism of action of Class I drugs.
2. Discuss synthesis, SAR and mechanism of action of warfarin.
3. Discuss SAR and synthesis of disopyramide phosphate.

Unit-IV Questions

1. Explain thyroid and antithyroid drugs with structures and uses.
2. Discuss corticosteroids in detail and give structures of cortisone and prednisolone.
3. Discuss nomenclature and stereochemistry of steroids.
4. Write a detailed note on oral contraceptives.
5. Write a detailed note on propylthiouracil.

Unit-V Questions

1. Classify local anesthetics with examples/structures and explain benzoic acid derivatives.
2. Classify antidiabetic agents and discuss SAR and synthesis of tolbutamide.
3. Discuss structural classification of local anesthetics and mechanism of action of benzocaine.